Versatile Heterocyclic Building Block: Imidazole is an important five-membered aromatic heterocyclic compound widely used as a key intermediate in pharmaceutical, agrochemical, and fine chemical synthesis.
Unique Amphoteric Properties: With both acidic and basic characteristics, imidazole readily forms salts with strong bases and exhibits versatile chemical reactivity in a variety of synthesis processes.
Excellent Catalytic Performance: The imidazole ring combines the chemical features of pyridine and pyrrole, making it an effective catalytic and acyl-transfer structural unit in numerous chemical and biochemical reactions.
Biologically Significant Structure: Imidazole derivatives are widely found in biological systems, including important biomolecules such as histidine, DNA-related compounds, and hemoglobin, highlighting their broad scientific and industrial value.
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Product Description
Product Description-Imidazole CAS#288-32-4
Imidazole (C₃H₄N₂) is a five-membered aromatic heterocycle in the diazole family, containing two nonadjacent ring nitrogen atoms. The lone pair on the 1-position nitrogen participates in cyclic conjugation, lowering its electron density and making the attached hydrogen readily dissociable as a proton.
Imidazole is amphoteric (both acidic and basic), forms salts with strong bases, and combines the chemical behavior of pyridine and pyrrole. In biology, the imidazole ring is a key structural element of histidine, acting as an acyl-transfer group in lipid hydrolysis and playing an important catalytic role in enzymatic reactions. Imidazole derivatives are widespread in living organisms and are more significant than imidazole itself in research and industry, with notable examples including DNA- and hemoglobin-related compounds.
Product Applications-Imidazole CAS#288-32-4
Imidazole is slightly more basic than pyrazole and readily forms stable salts such as picrates and nitrates. One of its key applications is purifying His-tagged proteins via immobilized metal affinity chromatography (IMAC): the target protein selectively binds nickel ions on the resin, and an imidazole-containing elution buffer competes for those nickel sites, releasing the protein in high purity.
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Chemical Properties-Imidazole CAS#288-32-4
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