Meglumine CAS#6284-40-8

Enhances Drug Solubility:Meglumine is widely used as a counter ion to significantly improve the solubility of poorly soluble drugs.

Improves Bioavailability: By increasing drug solubility, meglumine helps enhance the bioavailability and therapeutic effectiveness of active pharmaceutical ingredients.

Well-Established Pharmaceutical Counter Ion: It is a commonly used and well-recognized counter ion in pharmaceutical formulations, offering reliable and proven performance.

Favorable Chemical Properties: As an amino sugar derived from sorbitol with a pKa of about 9.6, meglumine provides suitable ionization characteristics for forming stable drug salts.

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Product Description

Product Description-Meglumine CAS#6284-40-8

White crystalline powder. Melting point 128–129°C. Readily soluble in water, slightly soluble in ethanol (1.2 g dissolves in 100 ml of ethanol at 25°C; 21 g dissolves at 70°C), and practically insoluble in chloroform. It has a slightly sweet taste with a salty, astringent undertone.

Product Applications-Meglumine CAS#6284-40-8

Diagnostic agents; solubilizing agents and surfactants for contrast media.

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Product Data

Chemical Properties-Meglumine CAS#6284-40-8

Melting point	129-131.5 °C (lit.)
Boiling point	331.88°C (rough estimate)
alpha	-16.5 º (c=10, H2O, on dry sub)
density	1.2669 (rough estimate)
bulk density	300kg/m3
refractive index	-16.5 ° (C=2, H2O)
RTECS	LZ4295770
storage temp.	2-8°C
solubility	H2O: 0.1 g/mL, clear, colorless
pka	pKa 9.39(H2O,t =30.0,I=0.05N2)(Approximate)
form	Crystalline Powder
color	White to almost white
PH	11 (10g/l, H2O, 20℃)
biological source	synthetic (organic)
Optical Rotation	[α]20/D 16.5±0.5°, c = 2% in H2O
Water Solubility	100 g/100 mL (25 ºC)
Sensitive	Air Sensitive & Hygroscopic
Merck	14,6078
BRN	385906
Major Application	pharmaceutical (small molecule)
Cosmetics Ingredients Functions	HAIR CONDITIONING
InChI	1S/C7H17NO5/c1-8-2-4(10)6(12)7(13)5(11)3-9/h4-13H,2-3H2,1H3/t4-,5+,6+,7+/m0/s1
InChIKey	MBBZMMPHUWSWHV-VZFHVOOUSA-N
SMILES	CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO
LogP	-3.370 (est)
NIST Chemistry Reference	N-methylglucamine(6284-40-8)
EPA Substance Registry System	Meglumine (6284-40-8)

Safety Information-Meglumine CAS#6284-40-8

Risk Statements	36/37/38
Safety Statements	24/25
WGK Germany	3
F	3-10-23
Autoignition Temperature	~662 °F
TSCA	TSCA listed
HS Code	29221980
Storage Class	11 - Combustible Solids
Toxicity	LD50 orally in Rabbit: > 5000 mg/kg

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